Key Publications
Murphy KR, Farrell JS, Bendig J, Mitra A, Luff C, Stelzer IA, Yamaguchi H, Angelakos CC, Choi M, Bian W, DiIanni T, Pujol EM, Matosevich N, Airan R, Gaudillière B, Konofagou E, Butts Pauly K, Soltesz I, de Lecea L. Optimized ultrasound neuromodulation for non-invasive control of complex behavior and physiology. Neuron (2024) Online ahead of print https://doi.org/10.1016/j.neuron.2024.07.002.
Jamiolkowski RM, Nguyen QA, Farrell JS, McGinn RJ, Hartmann DA, Nirschl JJ, Sanchez MI, Buch VP, Soltesz I. The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy. Nature Medicine (2024). Link
Dudok B, Fan LZ, Farrell JS, Malhotra S, Homidan J, Kim DK, Wenardy C, Ramakrishnan C, Li Y, Deisseroth K, Soltesz I. Retrograde endocannabinoid signaling at inhibitory synapses in vivo. Science 383: 967-970 (2024). Link
Farrell JS, Hwaun E, Dudok B, Soltesz I. Neural and behavioral state switching during hippocampal dentate spikes. Nature 628: 590-595 (2024). Link
Nguyen QA, Klein PM, Xie C, Benthall KN, Iafrati J, Homidan J, Bendor JT, Dudok B, Farrell JS, Gschwind TA, Porter CL, Keravala A, Dodson GS, Soltesz I. Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice. Nature Communications 15: 601 (2024). Link
George AG, Farrell JS, Colangeli R, Wall AK, Gom RC, Kesler MT, de la Hoz CL, Perera T, Rho JM, Kurrasch D, Teskey GC. Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia. Neuropharmacology 109513 (2023). Link
Murphy KR, Farrell JS, Gomez JL, Stedman QG, Li N, Leung S, Good CH, Qiu Z, Firouzi K, Butts Pauly K, Khuri-Yakub BT, Michaelides M, Soltesz I, de Lecea L. A tool for monitoring cell type specific focused ultrasound neuromodulation and control of chronic epilepsy. PNAS 119: e2206828119 (2022). Link
Szabo GG, Farrell JS, Dudok B, Hou W-S, Ortiz A, Varga C, Moolchand P, Gulsever CI, Gschwind T, Dimidschtein J, Capogna M, Soltesz I. Ripple-selective GABAergic projection cells in the hippocampus. Neuron 110: 1959-1977 (2022). Link
Liu A, Henin S, Abbaspoor S, Bragin A, Buffalo EA, Farrell JS, Foster DJ, Frank LM, Gedankien T, Gotman J, Guidera JA, Hoffman KL, Jacobs J, Kahana MJ, Li L, Liao Z, Lin JJ, Losonczy A, Malach F, van der Meer MA, McClain K, McNaughton BL, Norman Y, Navas-Olive A, de La Prida L, Rueckemann JW, Sakon JJ, Skelin I, Soltesz I, Staresina BP, Weiss SA, Wilson MA, Zaghloul KA, Zugaro M, Buzsáki G. A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations. Nature Communications 13: 6000 (2022). Link
Farrell JS, Lovett-Barron M, Klein PM, Sparks FT, Gschwind TA, Ortiz A, Ahanonu B, Terada S, Bradbury S, Oijala M, Huang E, Dudok B, Szabo G, Schnitzer MJ, Deisseroth K, Losonczy A, Soltesz I. Supramammillary regulation of locomotion and hippocampal activity. Science 374: 1492-1496 (2021). Link
Dong A, He K, Dudok B, Farrell JS, Guan W, Liput DJ, Puhl HL, Cai R, Duan J, Albarran E, Ding J, Lovinger DM, Li B, Soltesz I, Li Y. A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo. Nature Biotechnology 1-12 (2021). Link
Farrell JS, Colangeli R, Dong A, George AG, Addo-Osafo K, Kingsley PJ, Morena M, Wolff MD, Dudok B, He K, Patrick TA, Sharkey KA, Patel S, Marnett LJ, Hill MN, Li Y, Teskey GC, Soltesz I. In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity. Neuron 109: 2398-2403 (2021). Link
**On the Cover**
Dudok B, Klein PM, Hwaun E, Lee B, Yao Z, Fong O, Bowler JC, Terada S, Sparks FT, Szabo GG, Farrell JS, Berg J, Daigle TL, Tasic B, Dimidschstein J, Fishell G, Losonczy A, Zeng H, Soltesz I. Alternating sources of perisomatic inhibition during behavior. Neuron 109: 997-1012 (2021). Link
Farrell JS, Colangeli R, Dudok B, Wolff MD, Nguyen SL, Jackson J, Dickson CT, Soltesz I, Teskey GC. In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia. Scientific Reports 10: 14992 (2020). Link
Lee K, Bohnert S, Bouchard M, Vair C, Farrell JS, Teskey GC, Mikler J, Dunn JF. Quantitative T2 MRI is predictive of neurodegeneration following organophosphate exposure in a rat model. Scientific Reports 10: 13007 (2020). Link
Wolff MD, Farrell JS, Scantlebury MH, Teskey GC. Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling. Epilepsia 61: 1515-27 (2020). Link
Farrell JS, Nguyen QA, Soltesz I. Resolving the micro-macro disconnect to address core features of seizure networks. Neuron 101: 1016-28 (2019). Link
**On the Cover**
Farrell JS, Soltesz I. Plants come to mind: phytocannabinoids, endocannabinoids and the control of seizures. Addiction 114: 1343 (2019). Link
Farrell JS, Greba Q, Snutch TP, Howland JG, Teskey GC. Fast oxygen dynamics as a potential biomarker for epilepsy. Scientific Reports 8:1-7 (2018). Link
Boychuk JA, Farrell JS, Palmer LA, Singleton AC, Pittman QJ, Teskey GC. HCN channels segregate stimulation‐evoked movement responses in neocortex and allow for coordinated forelimb movements in rodents. The Journal of Physiology 595: 247-63 (2017). Link
Farrell JS, Colangeli R, Wolff MD, Wall AK, Phillips TJ, George A, Federico P, Teskey GC. Postictal hypoperfusion/hypoxia provides the foundation for a unified theory of seizure‐induced brain abnormalities and behavioral dysfunction. Epilepsia 58: 1493-501 (2017). Link
**On the Cover**
Farrell JS, Wolff MD, Teskey GC. Neurodegeneration and pathology in epilepsy: clinical and basic perspectives. In: Neurodegenerative diseases 317-34 (2017).
Farrell JS, Gaxiola-Valdez I, Wolff MD, David LS, Dika HI, Geeraert BL, Wang XR, Singh S, Spanswick SC, Dunn JF, Antle MC, Federico P, Teskey GC. Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent. eLife 5: e19352 (2016). Link
Farrell JS, Teskey GC. Epilepsy. In: The International Encyclopedia of Social and Behavioral Sciences. 2nd Ed. (2015).